Text parafrazat despre "There are two MAO isoforms that are pri-mary therapeutic targets MAO-A and MAO-B. The in-hibitory bi..."
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Textul Original
There are two MAO isoforms that are pri-mary therapeutic targets MAO-A and MAO-B. The in-hibitory binding site of both MOA-A and B are identical, the key difference lies in the recognition sites near their active sites. The MAO-B recognition site is smaller than that of MAO-A. This difference permits specific isoform targeting. Therefore, MAOIs can be classified based on whether they are selective or nonselective MAO-A/MAO-B inhibitors and , if their effect is reversible or irreversible.
Varianta Standard
There are two main isoforms of monoamine oxidase (MAO) that serve as primary therapeutic targets: MAO-A and MAO-B. The inhibitory binding sites for both MAO-A and MAO-B are the same; however, the significant distinction is found in the recognition sites located near their active sites. The recognition site for MAO-B is smaller compared to that of MAO-A. This variation allows for targeted treatment of specific isoforms. Consequently, MAO inhibitors (MAOIs) can be categorized based on their selectivity—whether they are selective or nonselective MAO-A/MAO-B inhibitors—and whether their effects are reversible or irreversible.